Nov 23, 2025
Alpha-Screening
Deron Smoot, Kalysha Melendez Hernandez, Kevin Chen, Koushik Das
Current DNA synthesis screening relies on sequence homology , a method easily bypassed by AI-enabled threat actors through deliberately mutated or obfuscated sequences. This creates an "uncomfortable asymmetry" where offensive capabilities are democratizing faster than our defensive infrastructure. We present Alpha-Screen, a proof-of-concept for a next-generation "defensive acceleration" . Instead of just checking sequence patterns, Alpha-Screen analyzes potential functions. It translates a given DNA sequence in all six reading frames and feeds the resulting potential proteins into a State-of-the-Art (SOTA) protein folding model (ESMFold) to predict 3D structure. This novelty of integrating the "Test" phase (structure/function) directly into the "Screen" phase allows the system to flag high-risk structural features, not just sequence similarity. This approach can catch mutated threats that evade current screens , providing a crucial early warning against novel biosecurity threats.
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Cite this work
@misc {
title={
(HckPrj) Alpha-Screening
},
author={
Deron Smoot, Kalysha Melendez Hernandez, Kevin Chen, Koushik Das
},
date={
11/23/25
},
organization={Apart Research},
note={Research submission to the research sprint hosted by Apart.},
howpublished={https://apartresearch.com}
}


