Nov 24, 2025

BioSecure: know-your-customer system for DNA synthesis companies

Phil Palmer, Ryan Teo, Michal Karlubík, Jamie Harris

Artificial intelligence accelerates biological design capabilities whilst lowering barriers to hazardous information, creating biosecurity challenges at the critical interface between digital and physical biology: DNA synthesis. We present BioSecure, a modular customer screening framework built during a 48-hour hackathon to address emerging threats from AI-designed biological sequences. The system integrates government-backed identity verification with liveness detection through Veriff, sanctions and watchlist screening, institutional legitimacy checks against the Research Organization Registry (ROR) and biosafety level databases, publication history verification via ORCID, and sequence screening using the ESM-C 300M protein language model. BioSecure synthesises these signals into cumulative risk assessment rather than binary accept/reject logic, functioning as a decision-support tool that preserves human authority over order fulfilment. The framework addresses a critical gap: whilst sequence screening adoption has improved, customer screening remains patchy and manual. We demonstrate that AI-enabled threats require AI-enabled defences, and that automated customer verification can complement sequence screening to create defence-in-depth against misuse of synthetic biology.

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Cite this work

@misc {

title={

(HckPrj) BioSecure: know-your-customer system for DNA synthesis companies

},

author={

Phil Palmer, Ryan Teo, Michal Karlubík, Jamie Harris

},

date={

11/24/25

},

organization={Apart Research},

note={Research submission to the research sprint hosted by Apart.},

howpublished={https://apartresearch.com}

}

Jul 28, 2025

Local Learning Coefficients Predict Developmental Milestones During Group Relative Policy Optimization

In this work, we investigate the emergence of capabilities in reinforcement learning (RL) by framing them as developmental phase transitions. We propose that the individual components of the reward function can serve as direct observables for these transitions, avoiding the need for complex, derived metrics. To test this, we trained a language model on an arithmetic task using Group Relative Policy Optimization (GRPO) and analyzed its learning trajectory with the Local Learning Coefficient (LLC) from Singular Learning Theory. Our findings show a strong qualitative correlation between spikes in the LLC—indicating a phase transition—and significant shifts in the model's behavior, as reflected by changes in specific reward components for correctness and conciseness. This demonstrates a more direct and scalable method for monitoring capability acquisition, offering a valuable proof-of-concept for developmental interpretability and AI safety. To facilitate reproducibility, we make our code available at \url{github.com/ilijalichkovski/apart-physics}.

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As AI systems scale into decentralized, multi-agent deployments, emergent vulnerabilities challenge our ability to evaluate and manage systemic risks.

In this work, we adapt classical epidemiological modeling (specifically SEIR compartment models) to model adversarial behavior propagation in AI agents.

By solving systems of ODEs describing the systems with physics-informed neural networks (PINNs), we analyze stable and unstable equilibria, bifurcation points, and the effectiveness of interventions.

We estimate parameters from real-world data (e.g., adversarial success rates, detection latency, patching delays) and simulate attack propagation scenarios across 8 sectors (enterprise, retail, trading, development, customer service, academia, medical, and critical infrastructure AI tools).

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As AI systems scale into decentralized, multi-agent deployments, emergent vulnerabilities challenge our ability to evaluate and manage systemic risks.

In this work, we adapt classical epidemiological modeling (specifically SEIR compartment models) to model adversarial behavior propagation in AI agents.

By solving systems of ODEs describing the systems with physics-informed neural networks (PINNs), we analyze stable and unstable equilibria, bifurcation points, and the effectiveness of interventions.

We estimate parameters from real-world data (e.g., adversarial success rates, detection latency, patching delays) and simulate attack propagation scenarios across 8 sectors (enterprise, retail, trading, development, customer service, academia, medical, and critical infrastructure AI tools).

Our results demonstrate how agent population dynamics interact with architectural and policy design interventions to stabilize the system.

This framework bridges concepts from dynamical systems and cybersecurity to offer a proactive, quantitative toolbox on AI safety.

We argue that epidemic-style monitoring and tools grounded in interpretable, physics-aligned dynamics can serve as early warning systems for cascading AI agentic failures.

Read More

Jul 28, 2025

Local Learning Coefficients Predict Developmental Milestones During Group Relative Policy Optimization

In this work, we investigate the emergence of capabilities in reinforcement learning (RL) by framing them as developmental phase transitions. We propose that the individual components of the reward function can serve as direct observables for these transitions, avoiding the need for complex, derived metrics. To test this, we trained a language model on an arithmetic task using Group Relative Policy Optimization (GRPO) and analyzed its learning trajectory with the Local Learning Coefficient (LLC) from Singular Learning Theory. Our findings show a strong qualitative correlation between spikes in the LLC—indicating a phase transition—and significant shifts in the model's behavior, as reflected by changes in specific reward components for correctness and conciseness. This demonstrates a more direct and scalable method for monitoring capability acquisition, offering a valuable proof-of-concept for developmental interpretability and AI safety. To facilitate reproducibility, we make our code available at \url{github.com/ilijalichkovski/apart-physics}.

Read More

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As AI systems scale into decentralized, multi-agent deployments, emergent vulnerabilities challenge our ability to evaluate and manage systemic risks.

In this work, we adapt classical epidemiological modeling (specifically SEIR compartment models) to model adversarial behavior propagation in AI agents.

By solving systems of ODEs describing the systems with physics-informed neural networks (PINNs), we analyze stable and unstable equilibria, bifurcation points, and the effectiveness of interventions.

We estimate parameters from real-world data (e.g., adversarial success rates, detection latency, patching delays) and simulate attack propagation scenarios across 8 sectors (enterprise, retail, trading, development, customer service, academia, medical, and critical infrastructure AI tools).

Our results demonstrate how agent population dynamics interact with architectural and policy design interventions to stabilize the system.

This framework bridges concepts from dynamical systems and cybersecurity to offer a proactive, quantitative toolbox on AI safety.

We argue that epidemic-style monitoring and tools grounded in interpretable, physics-aligned dynamics can serve as early warning systems for cascading AI agentic failures.

Read More

Jul 28, 2025

Local Learning Coefficients Predict Developmental Milestones During Group Relative Policy Optimization

In this work, we investigate the emergence of capabilities in reinforcement learning (RL) by framing them as developmental phase transitions. We propose that the individual components of the reward function can serve as direct observables for these transitions, avoiding the need for complex, derived metrics. To test this, we trained a language model on an arithmetic task using Group Relative Policy Optimization (GRPO) and analyzed its learning trajectory with the Local Learning Coefficient (LLC) from Singular Learning Theory. Our findings show a strong qualitative correlation between spikes in the LLC—indicating a phase transition—and significant shifts in the model's behavior, as reflected by changes in specific reward components for correctness and conciseness. This demonstrates a more direct and scalable method for monitoring capability acquisition, offering a valuable proof-of-concept for developmental interpretability and AI safety. To facilitate reproducibility, we make our code available at \url{github.com/ilijalichkovski/apart-physics}.

Read More

Jul 28, 2025

AI agentic system epidemiology

As AI systems scale into decentralized, multi-agent deployments, emergent vulnerabilities challenge our ability to evaluate and manage systemic risks.

In this work, we adapt classical epidemiological modeling (specifically SEIR compartment models) to model adversarial behavior propagation in AI agents.

By solving systems of ODEs describing the systems with physics-informed neural networks (PINNs), we analyze stable and unstable equilibria, bifurcation points, and the effectiveness of interventions.

We estimate parameters from real-world data (e.g., adversarial success rates, detection latency, patching delays) and simulate attack propagation scenarios across 8 sectors (enterprise, retail, trading, development, customer service, academia, medical, and critical infrastructure AI tools).

Our results demonstrate how agent population dynamics interact with architectural and policy design interventions to stabilize the system.

This framework bridges concepts from dynamical systems and cybersecurity to offer a proactive, quantitative toolbox on AI safety.

We argue that epidemic-style monitoring and tools grounded in interpretable, physics-aligned dynamics can serve as early warning systems for cascading AI agentic failures.

Read More

This work was done during one weekend by research workshop participants and does not represent the work of Apart Research.
This work was done during one weekend by research workshop participants and does not represent the work of Apart Research.